Guitar Hero: Aerosmith é uma versão especial da popular série de jogos Guitar Hero, que desta vez dedica-se exclusivamente a icônica banda de hard rock, Aerosmith. Assim como em seus predecessores, o título suporta a utilização do periférico em formato de guitarra — que contém cinco trastes, um interruptor que simula as palhetadas e uma alavanca.

De forma semelhante aos outros games da série, o game vai narrar a história da banda, desde o primeiro show até as maiores apresentações em estádios colossais. As músicas incluídas vão desde os maiores clássicos do grupo liderado por Steve Tyler, até faixas de artistas que inspiraram a banda.

Desta vez o jogador assume o papel dos guitarristas Joe Perry e Brad Whitford, bem como do baixista Tom Hamilton, sem esquecer-se da presença de palco do vocalista Steven Tyler e do baterista Joey Kramer.  

Tier 1: “Getting the Band Together” (Nipmuc High School)
1. “All the Young Dudes” by Mott the Hoople (cover)
2. “Draw the Line” by Aerosmith
3. “Dream Police” by Cheap Trick
4. “Make It” by Aerosmith (re-recorded)
5. “Uncle Salty” by Aerosmith

Tier 2: “First Taste of Success” (Max’s Kansas City)
6. “All Day and All of the Night” by The Kinks (cover)
7. “I Hate Myself for Loving You” by Joan Jett
8. “Movin’ Out” by Aerosmith (re-recorded)
9. “No Surprize” by Aerosmith
10. “Sweet Emotion” by Aerosmith

Tier 3: “The Triumphant Return” (The Orpheum)
11. “Complete Control” by The Clash
12. “Livin’ on the Edge” by Aerosmith
13. “Love in an Elevator” by Aerosmith
14. “Personality Crisis” by New York Dolls (cover)
15. “Rag Doll” by Aerosmith

Tier 4: “International Superstars” (Moscow)
16. “Bright Light Fright” by Aerosmith
17. “King of Rock” by Run-D.M.C.
18. “Nobody’s Fault” by Aerosmith
19. “She Sells Sanctuary” by The Cult
20. “Walk This Way” by Run-D.M.C. featuring Aerosmith

Tier 5: “The Great American Band” (Half Time Show)
21. “Always on the Run” by Lenny Kravitz
22. “Back in the Saddle” by Aerosmith
23. “Beyond Beautiful” by Aerosmith
24. “Dream On” by Aerosmith (re-recorded)
25. “Hard to Handle” by The Black Crowes (cover)

Tier 6: “Rock N Roll Legends” (Rock & Roll Hall of Fame)
26. “Cat Scratch Fever” by Ted Nugent
27. “Mama Kin” by Aerosmith (re-recorded)
28. “Sex Type Thing” by Stone Temple Pilots
29. “Toys In The Attic” by Aerosmith
30. “Train Kept A Rollin” by Aerosmith
–> 31. “Guitar Battle vs Joe Perry” by Joe Perry

Bonus Songs (The Vault)
32. “Combination” by Aerosmith
33. “Kings and Queens” by Aerosmith
34. “Let The Music Do The Talking” by Aerosmith
35. “Mercy” by Joe Perry
36. “Pandora’s Box” by Aerosmith
37. “Pink” by Aerosmith
38. “Rats In The Cellar” by Aerosmith
39. “Shakin’ My Cage” by Joe Perry
40. “Talk Talkin” by Joe Perry
41. “Walk This Way” by Aerosmith